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merlin version 4 will be released on 31st of October 2019

We are proud to announce that the latest version of merlin will be released on the 31st of October 2019, available for download in this website.

S2M2 - Summer School in Metabolic Modeling (3-7 June 2019)

BioSystems group is organizing a 5-day course on metabolic modelling – Summer School in Metabolic Modeling. The course will cover the full process from model reconstruction to phenotype prediction ns using genome-scale metabolic models. The focus of the course will be on user-friendly tools for metabolic model reconstruction (merlin) and simulation (Optflux) and to introduce experimental procedures to improve those models. See more at http://s2m2.bio.di.uminho.pt/

tutorial available

A tutorial on Reconstructing high-quality large-scale metabolic models with merlin was published in:
Metabolic Network Reconstruction and Modeling: Methods and Protocols, Vol. Methods in Molecular Biology 1716, Springer, 2018. ISBN: 978-1-4939-7528-0, 1-36

merlin is now published

Dias, O., Rocha, M., Ferreira, E.C. and Rocha, I. (2015) Reconstructing genome-scale metabolic models with merlin. Nucleic Acids Res., 10.1093/nar/gkv294.

TRIAGE is also published:

Dias, O., Gomes, D., Vilaca, P., Cardoso, J., Rocha, M., Ferreira, E., & Rocha, I. (2016). Genome-wide Semi-automated Annotation of Transporter Systems. IEEE/ACM Transactions on Computational Biology and Bioinformatics / IEEE, ACM, (1), 1–1. http://doi.org/10.1109/TCBB.2016.2527647


merlin is a simple, graphical and user-oriented solution for the reconstruction of genome-scale metabolic models.

It will guide you along the model reconstruction, providing several tools that help to improve and curate the model throughout the whole process.


Getting started